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Cell Cycle and Cancer Worksheet
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Cell Cycle and Cancer Worksheet
Based on the Amoeba Sisters: "The Cell Cycle (and Cancer)"
🔬 Part 1: Multiple Choice
Circle the best answer for each question.
1. Which of the following correctly lists the phases of the cell cycle in order?
G1 → S → G2 → Mitosis → Cytokinesis
S → G1 → G2 → Cytokinesis → Mitosis
Mitosis → G1 → S → G2 → Cytokinesis
G1 → G2 → S → Mitosis → Cytokinesis
2. During which phase of interphase does DNA replication occur?
G1 phase
S phase
G2 phase
M phase
3. What is the primary role of cell cycle checkpoints?
To speed up cell division so the body grows faster
To ensure each phase is completed correctly before the cell moves on
To trigger mutations in DNA
To produce energy for the cell during division
4. Cancer cells differ from normal cells because they:
Divide too slowly and eventually stop dividing
Ignore cell cycle checkpoints and divide uncontrollably
Undergo apoptosis more frequently than normal cells
Only divide in response to growth factors
5. Which of the following best describes a tumor suppressor gene?
A gene that promotes rapid, uncontrolled cell division
A gene that codes for proteins that slow down or stop the cell cycle
A gene found only in cancer cells
A gene that causes mutations during S phase
✅ Part 2: True or False
Write True or False on the line provided.
6. _______ Interphase is a resting stage where nothing important happens in the cell.
7. _______ Proto-oncogenes are normal genes that, when mutated, can become oncogenes and contribute to cancer.
8. _______ Apoptosis is a process of programmed cell death that helps prevent damaged cells from dividing uncontrollably.
9. _______ A single mutation in DNA is usually enough to cause cancer on its own.
✏️ Part 3: Short Answer
10. Describe what happens at the G1/S checkpoint. Why is this checkpoint important for preventing cancer?
11. In your own words, explain the difference between a benign tumor and a malignant tumor. Which is more dangerous and why?
12. How does understanding the cell cycle help scientists develop cancer treatments? Give at least one specific example.
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